PharmPK Discussion - Taurine analysis

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On 8 Sep 1998 at 14:12:24, Fabio MACCHI (fabio.macchi.-a-.zambongroup.com) sent the message


Dear colleagues,

Nobody knows a method for HPLC determination of Taurine in biological fluids?

Best regards in advance
Dr. Fabio Macchi
Pharmacokinetics Lab.-ZambonGroup S.p.A.
fabio.macchi.-a-.zambongroup.com

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On 9 Sep 1998 at 10:36:55, David_Bourne (david.-a-.pharm.cpb.uokhsc.edu) sent the message

[Two replies - db]

From: "JEFFREY LAKRITZ" 
Organization: MU Dept of Veterinary Med. & Surg.
To: PharmPK.-a-.pharm.cpb.uokhsc.edu
Date: Tue, 8 Sep 1998 20:44:00 CST
MIME-Version: 1.0
Subject: Re: PharmPK Taurine analysis
Priority: normal

Dear colleagues,

I think there is a method for deterimination of taurine using
HPLC-EC.  The mobile phase is fairly simple, 50 mM phosphate buffer,
with about 2-5% acetonitrile, and low pH (about pH 2.7?), possible a
modifier like octansulfonic acid or other related compounds.  Column
that might work would be a C18 5 um, 150 x 4.6 or 250 x 4.6.  I think
it was published in J. Chromatography A, and I saw it on a flyer that
ESA, (the company that makes the electrochemical detector sent to
me).  They are on the world wide web at ESAINC.com and are located in
Chelmsford Massachusetts.  If I can find the advertisement I can get
the exact reference for the method.  ESA can probably send a methods
sheet to you directly.
jeff lakritz
University of Missouri-Columbia
 Nobody knows a method for HPLC determination
of Taurine in biological fluids?

Best regards in advance
Dr. Fabio Macchi
Pharmacokinetics Lab.-ZambonGroup S.p.A.
fabio.macchi.-at-.zambongroup.com

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X-Originating-IP: [194.95.249.41]
From: "Krishna Devarakonda" 
To: PharmPK.aaa.pharm.cpb.uokhsc.edu
Subject: Re: PharmPK Taurine analysis
Date: Wed, 09 Sep 1998 03:55:23 PDT

HPLC analysis of taurine

Please refer to:

1. Qu et al. J.Chromatogr A, 1998, 798, 19-26

2. Suleiman et al. Cardiovascular Res. 1995, 30, 747-754.

D.R.Krishna,Ph.D
AvH Scientist
Dr.Margarete-Fischer-Bosch-Institue
of Clinical Pharmacology
Auerbachstr.112
70376 Stuttgart, Germany
Tel. Off: +49-711-8101-3753

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