PharmPK Discussion - Tumor Imaging

PharmPK Discussion List Archive Index page

On 14 Jan 1998 at 10:36:37, rajesh krishna (rkrishna.at.unixg.ubc.ca) sent the message


Hi all,

Our project is focused on the reversal of multidrug resistance using the
chemosensitizer, PSC 833 and liposome-encapsulated doxorubicin.  In order
to determine how the anticancer drug is localized within tumor tissue, we
plan to investigate the subcellular localization using confocal
mircoscopy.  However, it is likely that the sample handling procedures
used routinely for CFM will disrupt the membrane causing drug release from
liposome and eventual binding to DNA.  Are there non-invasive imaging
techniques that could be used to determine accurate subcellular
localization of the anticancer drug in tumor tissues and liver?  Any
thoughts on this is much appreciated and welcome.

Rajesh Krishna
BC Cancer Agency
Vancouver, BC
Editor, Liposome Drug Delivery Systems Home Page
http://members.tripod.com/~rkrishna/

Back to the Top

On 15 Jan 1998 at 11:11:37, Michael Silver (msilver.at.idt.net) sent the message


Dear Dr Krishna:

Is there any way you can radio label your delivery system?  That woud be
one way, as long as the radiolabelling doesn't change the pharmacokinetics
or dynamics of the drug.

Let me know if this helps!

Michael Silver
Bio-Imaigng Technologies, Inc
Mahwah NJ
201 760 9510
FAX 201 327 2106

Back to the Top

Want to post a follow-up message on this topic? If this link does not work with your browser send a follow-up message to PharmPK@boomer.org with "Tumor Imaging" as the subject

PharmPK Discussion List Archive Index page