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I am having a problem with WinNonlin that is really making my work
frustrating! I am wondering whether anyone else has come across this
problem or might know how to avoid it:
I am fitting a data set to my own model, and everything is working fine,
when suddenly a box pops up saying "Subscript out of range", and when I
click "OK", WinNonlin closes, taking all my work with it. This happens at
various and random times: sometimes during fitting, but also sometimes
when I just close a data set. I can't seem to find the cause at all. If
I don't click OK (which is my only option- there is not a "cancel"
button), I can't do anything in the program anyway- I can't even save my
data sets. I know this isn't a result of my model- it has happened using
WinNonlin's built-in models as well.
This has reached the highest level of frustration- I have had to start
over numerous times. It's wasting a lot of time and effort on my part.
Is there anyone who has heard of or experienced this problem? I'm about
at the end of my rope!
University of Arizona College of Pharmacy
Department of Pharmacy Practice and Science
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Hello Stacy Tannenbaum:
Regarding the Winnonlin error message 'subscript out of range', this
means that you must have a do-loop somewhere in your model and the way
you have the programming written it tries to go to a value of n out of
the range of the do-loop. If you say 'do n = 1 to 20' and somewhere
else have 'n = n + 1' then you will end up with a value of 21 for n.
There are only spaces in the matrix for 20 subsripted variables not 21,
so you get the 'subscript out of range'. Hope this is clear.
(415) 225-5847 Mailstop 70
From: "Dan Combs"
Date: Mon, 11 May 1998 14:29:09 -0700
Subject: Re: PharmPK WinNonlin help!
After more carefully reading your e-mail about the 'subsript out of
range' error message, I see that the error message occurs even using
Winnonlin canned library models. My only suggestion here is that you
have a defective copy of Winnonlin. You might want to contact
Statistical Consultants Inc. for a new copy. Or contact Pharsight Inc.
in Palo Alto, CA - since they now own Winnonlin.
(415) 225-5847 Mailstop 70
Date: Tue, 12 May 1998 08:33:00 +0100
Organization: Schwarz Pharma Group
Subject: re: PharmPK WinNonlin help!
Text: (18 lines follow)
Hi Stacey Tannenbaum,
I think the reason of your problem is the combination of the values of
initial parameters and the step size of the iteration procedure. If you
start the iteration a second time using the same conditions you will find
the same result 'out of range'. If you used initial parameter set calculated
(automatically,..by winnonlin) the next step should be to use the own
initial data set of parameters. Using the procedure with ruler, pencil and
logtransformed concentration vs time data you can 'read' most of this
parameters. Starting the iteration with this parameters you will find a
final result of winnonlin, If there is a realistic connection of your model
and data measured in your study.
Schwarz Pharma AG
Monheim am Rhein, Germany
Date: Tue, 12 May 1998 05:59:35 -0600
From: Vinay Desai
Subject: PharmPK WinNonlin help! -Reply
Encoding: 60 Text
I have used WinNonlin extensively and haven't experienced the
frustrations that you seem be having. "Subscript out of Range" is a
Visual Basic error message that is usually evoked when an unhandled
error or exception arises. What operating system are you using? What
version of WinNonlin are you using? If I am not mistaken the current
versions for WinNonlin are ver 1.1 for the standard edition and ver 1.5
for the professional edition. I suspect that the errors you are
encountering are due to mismatched dynamic link libraries (DLL's)
needed by Windows and or WinNonlin or interference from another
application that may be running. Do you have the latest patches from
Microsoft for your operating system- e.g. Service Pack 3 for Windows
NT 4.0. You might also want to reinstall the WinNonlin. Do you have
other applications running while you are modeling? Perhaps, you may
want to shut these apps down.
Hope this helps
[In a separate message from the original poster I learned that they had
received word from the publisher that a later version of WinNonlin should
fix the problem - db]
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